Jo Spencer has had a career-long interest in human immunology, in particular the structure and function of the gut-associated lymphoid tissue and the origin of human intestinal IgA plasma cells.

It has recently become evidence that intestinal immune system can shape many factors that regulate the entire systemic immune system and that failures in this system can lead to autoimmunity.  Her current research in the Department of Immunobiology at Guy’s hospital focuses on the association between intestinal autoimmunity  and autoimmunity, in particular systemic lupus erythematosus and granulomatosis with polyangiitis.