A new study called SKINDLE will test an experimental skin ointment for active skin lesions caused by Discoid or Systemic Lupus Erythematosus. The drug, called R333, is a potent, topical JAK and SYK inhibitor with the potential to prevent or diminish both acute and chronic phases of this disorder. DLE is a chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas.